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Expression of active Rap1a in RPE cells has no effect on VEGF, but increases junctional protein, cadherin, in RPE/choroids. Western blots of (a and b) VEGF protein, (c and d) phosphorylation of ERK1/2 (p-ERK1/2) and (e and f) pan-cadherin in retinal pigment epithelial (RPE)/choroids from Rap1b+/- mice treated with subretinal injection of PBS, scAAV2-Con or scAAV2-CARap1a (a, c and e are representative gels and b, d and f are densitometry of gels; *P < 0.05 versus scAAV2-Con).
