Table 4.
Details on 14 Decompensation Events in 11 Patients During Antiviral Therapy
| Patient ID | Decompensation Event | Regimen | Releated to Treatment | Timing of Event, wk | Past History of Decompensation | Treatment Outcome |
|---|---|---|---|---|---|---|
| 1 | Hepatic encephalopathy | SOF/RBV | N | 8.3 | Y | SVR |
| 2 | Hepatic encephalopathy | SOF/RBV | Y | 16.1 | Y | Relapse |
| 3 | Variceal hemorrhage | SOF/RBV | N | 11.7 | Y | Relapse |
| 4 | Hepatic encephalopathy | SOF/RBV | Y | 4.9 | Y | Relapse |
| 4 | Hepatic encephalopathy | SOF/RBV | Y | 24.4 | Y | Relapse |
| 5 | Variceal hemorrhage | SOF/RBV | Y | 0.4 | Y | SVR |
| 6 | Hepatic encephalopathy | SOF/RBV | Y | 0.1 | Y | Relapse |
| 7 | Hepatic encephalopathy | SOF/RBV | Y | 19.4 | Y | SVR |
| 7 | Hepatic encephalopathy | SOF/RBV | Y | 16.6 | Y | SVR |
| 8 | Hepatic encephalopathy | SOF/RBV | Y | 0.1 | Y | LTFU |
| 8 | Ascites | SOF/RBV | Y | 9 | Y | LTFU |
| 9 | Hepatic encephalopathy | SOF/RBV | N | 4.3 | Y | BT |
| 10 | Hepatic encephalopathy | SOF/RBV | Y | 4.9 | Y | BT |
| 11 | Ascites | SOF/RBV | Y | 13.3 | Y | SVR |
Abbreviations: BT, breakthrough (on treatment); LTFU, lost to posttreatment follow-up; SOF/RBV, sofosbuvir/ribavirin; SVR, sustained virologic response.