Table 1. . Polyethylenimine content and primary amine percentage in different preparations of lactic-co-glycolic acid-modified polyethylenimine polymers.
| LGA/PEI polymer | PEI content (%) | LGA content (%) | Primary amine (%) |
|---|---|---|---|
| PEI |
100 |
0 |
100 |
| LGA-PEI (0.5:1 w/w) or (1:1 n/n)† |
64.7 ± 1.6 |
35.3 |
49 ± 3 |
| LGA-PEI (1:1 w/w) or (2:1 n/n) |
48.0 ± 0.8 |
52 |
9.5 ± 2.1 |
| LGA-PEI (2:1 w/w) or (4:1 n/n) |
32.3 ± 1.4 |
68 |
11.3 ± 0.1 |
| LGA-PEI (5:1 w/w) or (10/1 n/n) | 15.7 ± 0.6 | 84 | 8.2 ± 0.2 |
†In this study, LGA-PEI polymer (0.5:1 w/w or 1:1 n/n) was selected for DNA loading and delivery experiments.
LGA-PEI: Lactic-co-glycolic acid-modified polyethylenimine; n/n: mole/mole; PEI: Polyethylenimine.