Table 2. . Zeta potential of LGA-PEI/DNA nanoparticles.
| Nanoparticles | w/w ratio | N/P ratio | Zeta potential (mV)† |
|---|---|---|---|
| 5 μg LGA-PEI/10 μg DNA |
0.5:1 |
2 |
-38.9 ± 3.3 |
| 10 μg LGA-PEI/10 μg DNA |
1:1 |
4 |
N/A |
| 15 μg LGA-PEI/10 μg DNA |
1.5:1 |
6 |
30 ± 1.4 |
| 20 μg LGA-PEI/10 μg DNA |
2:1 |
8 |
22 ± 8 |
| 25 μg LGA-PEI/10 μg DNA |
2.5:1 |
10 |
21.4 ± 0.4 |
| 35 μg LGA-PEI/10 μg DNA |
3.5:1 |
14 |
27.5 ± 4.3 |
| 10 μg PEI/10 μg DNA |
1:1 |
6 |
57.5 ± 1.5 |
| 20 μg PEI/10 μg DNA | 2:1 | 12 | 63.8 ± 4.6 |
†LGA-PEI (0.5:1 w/w) polymer was used.
Zeta potential was measured in distilled water at ambient temperature.
LGA-PEI: Lactic-co-glycolic acid-modified polyethylenimine.