Table 1.

Oncolytic viruses that have had applications to pediatric tumors

Virus	Deletions/mutationsa	Foreign gene/promoter insertionsa	Pediatric tumor targets	References
HSV-1(F)
M002	γ1 34.5 both copies	mIL-12	Neuroblastoma, hepatoblastoma, malignant rhabdoid renal tumor, renal sarcoma, rhabdomyosarcoma, medulloblastoma, glioblastoma	9–15
G207	γ1 34.5 both copies	lacZ	Rhabdomyosarcoma, osteosarcoma, medulloblastoma, glioblastoma	6, 10–11
HSV-1(17)
HSV1716 (Seprehvir)	RL1 both copies		Neuroblastoma	8
Seneca Valley			Retinoblastoma, glioma, neuroblastoma, rhabdomyosarcoma	19, 21–22
Reovirus			Medulloblastoma, rhabdomyosarcoma, Ewing sarcoma, synovial sarcoma, lymphoma	34, 36–37
Vaccinia
Western Reserve, vvDD	Both copies TK and vaccinia growth factor		Atypical teratoid rhabdoid tumor, neuroblastoma, osteosarcoma, rhabdomyosarcoma	53
JX-594	TK gene both copies	Human GM-CSF and lacZ insertion into the TK gene region	Pediatric solid tumors	54

Note:

^aBlank spaces in the table are because they do not have deletions or foreign gene insertions.

Abbreviations: HSV, herpes simplex virus; mIL-12, murine interleukin-12; vvDD, double-deleted vaccinia virus; TK, thymidine kinase; GM-CSF, granulocyte macrophage colony-stimulating factor.