Table 12.
Top enriched GO terms (analysis using the biological process category) derived by genes corresponding to CpG sites selected by GoRevenge-based selection (a) and genes corresponding to CpG sites selected by evolutionary selection (b). (a) Using GORevenge results; and (b) using evolutionary selection results.
| GO ID | GO Description | p-Value | Enrichment | |
|---|---|---|---|---|
| (a) | ||||
| 1 | GO:0048709 | oligodendrocyte differentiation | 5.52 × 10−13 | 9/21 |
| 2 | GO:0044281 | small molecule metabolic process | 1.50 × 10−12 | 66/1530 |
| 3 | GO:0007411 | axon guidance | 1.92 × 10−12 | 29/345 |
| 4 | GO:0046777 | protein amino acid autophosphorylation | 1.93 × 10−12 | 21/171 |
| 5 | GO:0051216 | cartilage development | 3.58 × 10−12 | 14/90 |
| 6 | GO:0030900 | forebrain development | 3.86 × 10−12 | 15/87 |
| 7 | GO:0009790 | embryo development | 3.97 × 10−12 | 24/154 |
| 8 | GO:0007420 | brain development | 4.82 × 10−12 | 27/225 |
| 9 | GO:0001701 | in utero embryonic development | 5.75 × 10−12 | 36/256 |
| 10 | GO:0048011 | nerve growth factor receptor signaling pathway | 5.89 × 10−12 | 36/286 |
| (b) | ||||
| 1 | GO:0033603 | positive regulation of dopamine secretion | 3.44 × 10−7 | 3/6 |
| 2 | GO:0016458 | gene silencing | 7.95 × 10−7 | 3/7 |
| 3 | GO:0007411 | axon guidance | 7.50 × 10−6 | 15/345 |
| 4 | GO:0035249 | synaptic transmission, glutamatergic | 8.03 × 10−6 | 4/23 |
| 5 | GO:0045662 | negative regulation of myoblast differentiation | 1.07 × 10−5 | 3/12 |
| 6 | GO:0030900 | forebrain development | 1.29 × 10−5 | 7/87 |
| 7 | GO:0043523 | regulation of neuron apoptosis | 1.85 × 10−5 | 4/27 |
| 8 | GO:0001501 | skeletal system development | 2.14 × 10−5 | 9/152 |
| 9 | GO:0031069 | hair follicle morphogenesis | 2.23 × 10−5 | 4/28 |
| 10 | GO:0048663 | neuron fate commitment | 2.66 × 10−5 | 4/29 |