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. 2016 Jun 30;5(9):1277–1288. doi: 10.5966/sctm.2015-0223

Figure 3.

Figure 3.

Early protective effect of stromal vascular fraction (SVF) preischemic administration on acute renal IR injury. (A, B): Rats that received SVF administration showed significantly lower BUN (A) and SCr (B) values at 12, 24, and 72 hours after IR compared with control group. (C–E): SVF administration could also significantly reduce tubular injury score of kidneys in rats at 12 (C), 24 (D), and 72 (E) hours after IR compared with the control group. Although there was no significant difference in renal function and histopathological score between preischemic and postischemic groups, preischemic administration of SVF still contributed to lower BUN and SCr values, as well as reduced tubular injury, compared with postischemic administration. (F, G): Representative images of H&E staining preformed on sections of kidneys at 12, 24, and 72 hours after IR in different groups (magnification, ×400). Scale bars = 50 μm. ∗, p < .05 (vs. sham, IR+SVF pre-I, and IR+SVF post-I). Abbreviations: BUN, blood urea nitrogen; IR, ischemia/reperfusion; PBS, phosphate-buffered saline; SCr, serum creatinine; SVF Post-I, postischemic administration of stromal vascular fraction; SVF Pre-I, preischemic administration of stromal vascular fraction.