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iPSC hepatocytes express a higher degree of maturity and albumin synthesis within ECM scaffolds. Graphs show albumin production (A), AFP biosynthesis (B), and albumin/AFP protein synthesis ratio (C) in iPSC hepatocytes within ECM scaffolds, PLLA-collagen scaffolds, and sandwich controls throughout 14 days of culture (∗∗, p < .01; n = 4 for each group). Abbreviations: AFP, α-fetoprotein; ECM, extracellular matrix; iPSC, induced pluripotent stem cell; PLLA, poly-l-lactic acid.
