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. 2016 Jul 15;5(9):1257–1267. doi: 10.5966/sctm.2015-0235

Figure 6.

Figure 6.

ECM scaffolds confer increased P450 activity to iPSC hepatocytes. (A): CYP2C9, CYP3A4, and CYP1A2 activity in iPSC hepatocytes within ECM scaffolds, PLLA-collagen scaffolds, and sandwich control environments at 3, 7, and 14 days of culture. (B): Response of iPSC hepatocytes to treatment with P450 inducers, rifampicin (CYP2C9 and CYP3A4) and 3-methylcholanthrene (CYP1A2), within ECM scaffolds, PLLA-collagen scaffolds, and sandwich controls at day 14 (∗, p < .05; ∗∗, p < .01; n = 3 for each group at each time point). Abbreviations: ECM, extracellular matrix; iPSC, induced pluripotent stem cell; ND, not detected; PLLA, poly-l-lactic acid.