Table 2. Two independent association signals at the 1p11.2 locus: Association results for breast cancer risk among European women in BCAC, by tumor characteristic.
| Tumor Characteristic | Cases (N) | Signal | SNP | OR (95% CI)a | P-trend | P- heterogeneityb |
|---|---|---|---|---|---|---|
| ER Status | ||||||
| ER-positive | 6,315 | 1 | rs11249433 | 1.12 (1.10–1.15) | 4.09E-23 | |
| ER-negative | 21,610 | 1.00 (0.95–1.05) | 0.90 | 9.88E-09 | ||
| ER-positive | 6,315 | 2 | rs146784183 | 0.86 (0.82–0.89) | 1.48E-12 | |
| ER-negative | 21,610 | 0.99 (0.92–1.06) | 0.68 | 8.41E-05 | ||
| Tumor Grade | ||||||
| Well-differentiated | 5,917 | 1 | rs11249433 | 1.18 (1.14–1.23) | 5.63E-17 | |
| Moderately-differentiated | 13,561 | 1.13 (1.10–1.16) | 3.88E-17 | |||
| Poorly-differentiated | 8,784 | 1.02 (0.98–1.05) | 0.27 | 8.90E-11 | ||
| Well-differentiated | 5,917 | 2 | rs146784183 | 0.84 (0.77–0.90) | 3.23E-06 | |
| Moderately-differentiated | 13,561 | 0.85 (0.81–0.90) | 6.45E-09 | |||
| Poorly-differentiated | 8,784 | 0.96 (0.90–1.02) | 0.20 | 8.80E-04 | ||
| Histology | ||||||
| Ductal/Mixed | 22,308 | 1 | rs11249433 | 1.08 (1.05–1.10) | 5.07E-09 | |
| Lobular | 3,747 | 1.28 (1.22–1.35) | 1.15E-23 | |||
| Other | 2,563 | 1.12 (1.05–1.19) | 0.0002 | 7.60E-11 | ||
| Ductal/Mixed | 22,308 | 2 | rs146784183 | 0.90 (0.86–0.94) | 1.69E-06 | |
| Lobular | 3,747 | 0.81 (0.74–0.89) | 8.07E-06 | |||
| Other | 2,563 | 0.90 (0.81–1.00) | 0.05 | 0.11 |
aOdds ratios (OR) and 95% confidence intervals (95% CI) were estimated from logistic regression adjusted for study site and 7 principal components. The common allele was the referent for calculating odds ratio; the G-allele for both rs11249433 and rs146784183.
bP-heterogeneity tests whether SNP associations differ significantly by tumor characteristic.