Figure 1. Spontaneous seizures and increased locomotor activities in Prmt1+/- mice.

(a) reduced expression of Prmt1 in Prmt1+/- mice, compared to WT control mice. (b) Representative traces of seizure activities: short (upper) or long (middle and lower) duration of epileptiform activity. (c) A colored power spectrum of the trace shown in b. (d–g) The mean bar graphs of seizure spike frequency (d) duration (e), number of seizures per day (f), and seizure scores (g) in WT (n = 6) and Prmt1+/- mice (n = 8). (h) The WT and the Prmt1+/- mice spent similar amounts of times in the center of the open-field box. (i) The Prmt1+/- mice moved a longer distance than did the WT mice. (j) Total distance moved for 30 min. *p<0.05 by Student’s t-test.

DOI: http://dx.doi.org/10.7554/eLife.17159.003