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. Author manuscript; available in PMC: 2017 Sep 15.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Jul 30;26(18):4487–4491. doi: 10.1016/j.bmcl.2016.07.071

Table 2.

Structure and activities of analogs 8a.

graphic file with name nihms808861u2.jpg
Compound X Y hM5 Percent inhibition
4 (VU0549108) S O 84% (hM5 IC50 = 5.23 μM)
8a S S 86%
8b O O 45%
8c O CH2 37%
a

Average of three determinations with hM5 cells with an EC80 of ACh as a single point % inhibition at 10 μM. If not IC50 reported, the IC50 was >10 μM.