Table 3.

Structure and activities of analogs 9 ^a.

Compound	Ar	hM5 Percent inhibition
4 (VU0549108)	1,3,5-TriMe-1H-4-pyrazole	88% (hM5 IC50 = 6.18 μM)
9a	1-Me-1H-4-pyrazole	27%
9b	1,3-DiMe-1H-4-pyrazole	Inactive
9c	1,5-DiMe-1H-4-pyrazole	83%
9d	3-Cl-4-F-phenyl	83%
9e	3,5-DiF-phenyl	62%
9f	3,4,5-TriF-phenyl	55%
9g	3,5-DiMe-4-isoxazole	40%
9h	1-Me-4-imidazole	Inactive

^aAverage of three determinations with hM₅ cells with an EC₈₀ of ACh as a single point % inhibition at 10 μM. If not IC₅₀ reported, the IC₅₀ was >10 μM.