Table 2.
Baseline Patient Characteristics and Comorbidities by International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) Code†
| Characteristics and Comorbidities | Case n (%) |
Control n (%) |
P-value |
|---|---|---|---|
| INFECTIOUS AND PARASITIC DISEASES (001–139) | 97(26) | 60 (16) | 0.001 |
| INTESTINAL INFECTIOUS DISEASES (001–009) | 15 (4) | 5 (1) | 0.039 |
| OTHER BACTERIAL DISEASES (030–041) | 34 (9) | 13 (3) | 0.002 |
| MYCOSES (110–118) | 45 (12) | 23 (6) | 0.007 |
| NEOPLASMS (140–239) | 367 (98) | 351 (94) | 0.004 |
| DIGESTIVE ORGANS AND PERITONEUM (150–159) | 95 (25) | 55 (15) | <0.001 |
| RESPIRATORY AND INTRATHORACIC ORGANS (160–165) | 67 (18) | 37 (10) | 0.002 |
| BONE,CONNECTIVE TISSUE,SKIN, AND BREAST (170–176) | 80 (21) | 107 (29) | 0.028 |
| OTHER AND UNSPECIFIED SITE (190–199) | 249 (67) | 184 (49) | <0.001 |
|
ENDOCRINE, NUTRITIONAL AND METABOLIC DISEASES, AND IMMUNITY DISORDERS (240–279) |
223 (60) | 169 (45) | <0.001 |
| OTHER METABOLIC AND IMMUNITY DISORDERS (270–279) | 185 (49) | 136 (36) | <0.001 |
| DISEASES OF THE BLOOD AND BLOOD-FORMING ORGANS (280–289) | 150 (40) | 100 (27) | <0.001 |
| MENTAL DISORDERS (290–319) | 112 (30) | 86 (23) | 0.038 |
| OTHER PSYCHOSES (295–299) | 32 (9) | 16 (4) | 0.024 |
| DISEASES OF THE CIRCULATORY SYSTEM (390–459) | 300 (80) | 216 (58) | <0.001 |
| DISEASES OF PULMONARY CIRCULATION (415–417) | 38 (10) | 5 (1) | <0.001 |
| OTHER FORMS OF HEART DISEASE (420–429) | 126 (34) | 90 (24) | 0.005 |
| DISEASES OF VEINS AND LYMPHATICS, AND OTHER DISEASES OF CIRCULATORY SYSTEM (451–459) |
188 (50) | 50 (13) | <0.001 |
| DISEASES OF THE RESPIRATORY SYSTEM (460–519) | 198 (53) | 167 (45) | 0.028 |
| OTHER DISEASES OF THE UPPER RESPIRATORY TRACT(470–478) | 49 (13) | 31 (8) | 0.044 |
| OTHER DISEASES OF RESPIRATORY SYSTEM (510–519) | 129 (34) | 78 (21) | <0.001 |
| DISEASES OF THE DIGESTIVE SYSTEM (520–579) | 230 (62) | 164 (44) | <0.001 |
| DISEASES OF ORAL CAVITY, SALIVARY GLANDS, AND JAW (520–529) | 59 (16) | 35 (9) | 0.011 |
| DISEASES OF ESOPHAGUS, STOMACH, AND DUODENUM (530–539) | 96 (26) | 62 (17) | 0.003 |
| NONINFECTIOUS ENTERITIS AND COLITIS (555–558) | 41 (11) | 22 (6) | 0.017 |
| OTHER DISEASES OF DIGESTIVE SYSTEM (570–579) | 85 (23) | 49 (13) | <0.001 |
| SYMPTOMS, SIGNS, AND ILL-DEFINED CONDITIONS (780–799) | 316 (84) | 289 (77) | 0.015 |
| SYMPTOMS (780–789) | 290 (78) | 237 (63) | <0.001 |
| ILL-DEFINED AND UNKNOWN CAUSES OF MORBIDITY AND MORTALITY (797– 799) |
160 (43) | 121 (32) | 0.004 |
| INJURY AND POISONING (800–999) | 196 (52) | 147 (39) | <0.001 |
| POISONING BY DRUGS, MEDICINAL AND BIOLOGICAL SUBSTANCES (960–979) | 57 (15) | 24 (6) | <0.001 |
| COMPLICATIONS OF SURGICAL AND MEDICAL CARE, NOT ELSEWHERE CLASSIFIED 996–999) |
97 (26) | 60 (16) | 0.001 |
†
ICD-9-CM chapters are capitalized and subchapter categories are indented. All venous thromboembolism ICD-9 codes were excluded.