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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Cell Calcium. 2016 Mar 11;60(2):123–132. doi: 10.1016/j.ceca.2016.02.012

Figure 2. Basic macroautophagy process.

Figure 2

Shows a schematic diagram of the basic autophagy process. This process is divided into three processes of a) Initiation b) Elongation and c) Maturation. On stimulation with external environmental stimulus like cells stress, nutrient depletion, hypoxia, etc. the initiation process of autophagy starts with the activation of autophagy-related proteins (ATG) and activation of a complex of class III phoshoinositide 3-kinase VPS34 and beclin 1. The elongation and shape of the autophagosome are controlled by two protein conjugation system, the ATG12 conjugation and LC3 conjugation. During maturation the lysosomes associated autophagosomes are degraded into autolysosomes.