Table 3.

Mitochondria Stress Test Results from Primary Culture Human Lens Epithelial Cells

Patient Characteristic	Baseline OCR (fmol/min/cell)	Maximal OCR (fmol/min/cell)	O2-dependent ATP Production (%)	Proton Leak (%)	Spare Resp. Capacity (fmol/min/cell)	Baseline ECAR (μpH/min/cell)
Age ≤69 years	2.86*	5.28	32%	68%	2.37	2.04
Age ≥70 years	2.21	4.33	35%	65%	2.12	1.76
Non-Diabetic	2.79*	5.20	33%	67%	2.41	1.93
Diabetic	2.02	3.96	34%	66%	1.94	1.86
No Glaucoma	2.83*	5.46*	33%	67%	2.59	2.13
Glaucoma	2.27	4.17	33%	67%	1.90	1.68
Female	2.63	4.85	32%	68%	2.19	2.09
Male	2.39	4.76	35%	65%	1.57	1.51
Caucasian	2.57	4.69	32%	68%	2.10	1.68
African American	2.53	5.05	36%	64%	2.53	2.31
Total (n=69)	2.55	4.82	33%	67%	2.27	1.91

^*p<0.05

OCR = Oxygen Consumption Rate, ECAR = Extracellular Acidification Rate