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. 2016 Aug 24;6(1):56. doi: 10.1186/s13568-016-0226-8

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Therapeutic effects in the immunocompetent BALB/c mice with highly aggressive tumors elicited by ST8-mediated secretion of Endostatin. a Potent treatment of large established tumors with ST8/pSEndo. CT26 murine tumor cells were implanted subcutaneously into BALB/c mice, and then the mice bearing large tumors received intravenous injections of the indicated strains. Values are expressed as mean ± SD (n = 5). **P < 0.01 compared with vector control ST8/pSGFP. b Tumor proliferation was examined by Ki67 expression of primary tumors from ST8/pSGFP and ST8/pSEndo treated mice. Scale bar 100 μm. c No apparent damages were found in any of the organs in the ST8/pSEndo treatment group. Scale bar 100 μm