Figure 3. Haematopoietic compartment-specific detection of clonal SNVs in NHS participants.

Paired buffy coat samples from 13 individuals were sorted into B lymphocyte (pink), T lymphocyte (purple) and myeloid (blue) compartments using flow cytometry. For each NHS participant ID (PID), a single SNV, detected by ECS, was selected for compartment-specific quantification by ddPCR. Variants detected in both time points were connected with a line. The VAF measured by ddPCR in the bulk sample (green) was included for comparison.