Table 3.
Mostly likely SJS-active and inactive drugs in DrugBank (as predicted by Dragon-RF model)
| VigiBase | Chemo Text | Micromedex | ||||||
|---|---|---|---|---|---|---|---|---|
| DrugBank Identification | Predicted Value | standard deviation | Name | SJS Reports | All ADR Reports | IC a | SJS Articles b | SJS |
| Predicted Inducers (from DrugBank) | ||||||||
| DB01581 | 0.978 | 0.010 | Sulfamerazine | 0 | 1 | −0.01 | 2 | No |
| DB01332 | 0.967 | 0.006 | Ceftizoxime | 2 | 748 | −0.26 | 0 | Yes |
| DB00493 | 0.966 | 0.016 | Cefotaxime | 40 | 7550 | 0.66 | 15 | Yes |
| DB00576 | 0.964 | 0.007 | Sulfamethizole | 5 | 490 | 1.37 | 5 | Yes |
| DB01325 | 0.963 | 0.007 | Quinethazone | 0 | 25 | −0.22 | 0 | No |
| DB00880 | 0.959 | 0.040 | Chlorothiazide | 2 | 800 | −0.34 | 1 | Yes |
| DB00891 | 0.955 | 0.011 | Sulfapyridine | 0 | 29 | −0.25 | 2 | No |
| DB01333 | 0.951 | 0.012 | Cefradine | 3 | 994 | −0.12 | 1 | No c |
| DB00301 | 0.937 | 0.020 | Flucloxacillin | 29 | 5272 | 0.71 | 3 | No |
| DB01607 | 0.937 | 0.006 | Ticarcillin | 2 | 338 | −0.11 | 0 | Yes |
| Predicted Noninducers (from DrugBank) | ||||||||
| DB00294 | 0.066 | 0.031 | Etonogestrel | 1 | 4443 | −3.35 | 0 | No c |
| DB01357 | 0.084 | 0.036 | Mestranol | 0 | 26 | −0.23 | 2 | No |
| DB00202 | 0.099 | 0.144 | Succinylcholine | 4 | 3581 | −1.46 | 0 | No |
| DB01160 | 0.100 | 0.080 | Dinoprost | 0 | 161 | −1.05 | 0 | No |
| DB01088 | 0.103 | 0.020 | Iloprost | 1 | 1518 | −1.88 | 0 | No |
| DB01049 | 0.109 | 0.037 | Ergoloid mesylate | 2 | 171 | 1.23 | 0 | No |
| DB00966 | 0.110 | 0.023 | Telmisartan | 8 | 4845 | −0.96 | 0 | No c |
| DB01089 | 0.120 | 0.044 | Deserpidine | 0 | 9 | −0.08 | 0 | No |
| DB04834 | 0.123 | 0.079 | Rapacuronium | 0 | 112 | −0.80 | 0 | No |
| DB00654 | 0.124 | 0.042 | Latanoprost | 3 | 5423 | −2.40 | 1 | No c |
| Known Inducers (from reference set) | ||||||||
| NA | NA | NA | Sulfamethoxazole | 37 | 971 | 1.43 | 104 | Yes |
| NA | NA | NA | Amoxicillin | 648 | 48501 | 1.36 | 44 | Yes |
| Known Noninducers (from reference set) | ||||||||
| NA | NA | NA | Progesterone | 0 | 3825 | −4.72 | 0 | No c |
| NA | NA | NA | Vardenafil | 0 | 4506 | −4.95 | 0 | No |
Abbreviations: SJS, Stevens-Johnson syndrome; RF, Random Forest; SD, standard deviation; IC, information component; ADR, adverse drug reaction; NA, not applicable.
a Information component (IC) is a disproportionality frequency measuring the number of SJS reports lower than or higher than expected in VigiBase.
b Number of articles in Medline matching the search terms [drugname] AND “Stevens-Johnson syndrome” [MeSH] OR “erythema multiforme” [MeSH] OR “epidermal necrolysis, toxic” [MeSH] Filters: Humans (as of Februrary 2013).
c Hypersensitivity reaction although SJS was not explicitly mentioned.