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. 2016 Aug 15;12(9):1140–1149. doi: 10.7150/ijbs.15938

Figure 7.

Figure 7

The relationship between the neuron cells decrease and the TDP-43 protein increase in the cervical, thoracic and lumbar segments of spinal cord at the different stages of the SOD1 wild-type and G93A transgenic mice. The increase of neuron death was consistent with the increase of TDP-43 protein in the cervical, thoracic and lumbar segment of spinal cord and at the onset and progression stages of the SOD1 wild-type and G93A transgenic mice, and the relationship between the neuron cells decrease and the TDP-43 protein increase in the SOD1 G93A transgenic mice was particularly significant compared with that of the wild-type transgenic mice. The results indicated that the increase of TDP-43 protein contributed to the progressive neuron death in the development of ALS.