Table 1.
In vitro antiproliferative studies of Ru(III)-Schiff base complexes against TK-10, UACC-62, and MCF-7 cell lines.
| Compounds | Molecular formula | Anticancer activity IC50 (µM) 48 h | ||
|---|---|---|---|---|
| TK-10 | UACC-62 | MCF-7 | ||
| [Ru(DAE)Cl2(H2O)] | C18H24N3O4RuCl2 | 9.06 ± 1.18 | 6.44 ± 0.38 | 3.57 ± 1.09 |
| [Ru(HME)Cl2(H2O)] | C18H23N2O6RuCl2 | 41.09 ± 4.44 | 6.31 ± 1.47 | 4.88 ± 1.28 |
| [Ru(DEE)Cl2(H2O)] | C17H20N2O4RuCl3 | 13.10 ± 2.81 | 5.14 ± 1.09 | 3.43 ± 1.48 |
| Parthenolide∗ | C15H20O3 | 0.50 ± 1.43 | 0.89 ± 2.18 | 0.44 ± 2.02 |
∗Standard cytotoxin drug: cell lines were treated with different concentrations of the compounds to achieve 50% inhibition of the culture growth when cultured for 48 h. Value represents mean ± SD of three independent experimentations.