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. 2016 Jul 18;6(11):1792–1809. doi: 10.7150/thno.14584

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Class comparison of male symptomatic V30M TTR FAP patients and asymptomatic V30M carriers. (a) ROC curve for the SVM best model best-fit classifier for symptomatic vs. asymptomatic FAP male patients. This classifier comprised 200 genes had an AUC of 0.8268 and sensitivity, specificity, PPV and NPV of 80%, 82%, 84% and 79%, respectively. (b) The Harrell bootstrapping plot of the “bias-corrected” AUCs for male specific classifiers of different feature sizes (20-70) using a logistic regression model. The male signatures achieved AUCs >80% when more than 50 genes were used.

Class comparison of male symptomatic V30M TTR FAP patients and asymptomatic V30M carriers. (a) ROC curve for the SVM best model best-fit classifier for symptomatic vs. asymptomatic FAP male patients. This classifier comprised 200 genes had an AUC of 0.8268 and sensitivity, specificity, PPV and NPV of 80%, 82%, 84% and 79%, respectively. (b) The Harrell bootstrapping plot of the “bias-corrected” AUCs for male specific classifiers of different feature sizes (20-70) using a logistic regression model. The male signatures achieved AUCs >80% when more than 50 genes were used.