Table 2.
Demographic characteristics for all study patients and carriers.
| Discovery Set of FAP Patients and asymptomatic carriers (n=104) | Validation Set of FAP Patients and asymptomatic carriers (n=79) | |||||
|---|---|---|---|---|---|---|
| Characteristic | Asymptomatic (n=51) | Symptomatic (n=53) | p | Asymptomatic (n=35) | Symptomatic (n=44) | p |
| Sex—Female (n (%)) | 27 (52.9) | 28 (52.8) | 18 (51.4) | 23 (52.3) | ||
| Age (years) (mean (SD)) | 35.4 (11.9) | 45.2 (14.8) | .0003 | 31.1 (9.4) | 44.0 (12.0) | <.0001 |
| BMI (kg/m2) (mean (SD)) | 25.5 (4.9) | 23.5 (5.0) | .05 | 24.4 (3.4) | 24.3 (5.8) | .90 |
| (n=48) | (n=49) | (n=35) | (n=40) | |||
| Parental Inheritance (n (%)) | .27 | .70 | ||||
| Mother | 26 (51.0) | 21 (39.6) | 19 (45.7) | 22 (50.0) | ||
| Father | 24 (47.1) | 24 (45.3) | 16 (54.3) | 17 (38.6) | ||
| Both | 1 (2.0) | 0 | 5 (11.4) | |||
| Unknown | 8 (15.1) | |||||
| WBC (mean (SD)) | 6.6 (1.7) | 7.6 (2.0) | .01 | 6.8 (2.0) | 7.6 (2.4) | .06 |
| (n=48) | (n=49) | (n=33) | (n=44) | |||
| Platelets (mean (SD)) | 236.7 (49.7) | 236.8 (61.2) | .99 | 233.1 (48.9) | 260.2 (56.2) | .03 |
| (n=48) | (n=49) | (n=33) | (n=43) | |||
| Alkaline phosphatase (mean (SD)) | 55.7 (16.5) | 63.7 (14.9) | .02 | 53.3 (13.0) | 70.9 (28.5) | .007 |
| (n=41) | (n=47) | (n=23) | (n=43) | |||
| AST (mean (SD)) | 22.3 (8.7) | 26.3 (15.6) | .15 | 20.9 (6.5) | 22.3 (6.9) | .42 |
| (n=41) | (n=48) | |||||
| ALT (mean (SD)) | 24.2 (14.8) | 27.3 (23.3) | .46 | 20.5 (9.3) | 23.7 (11.6) | .26 |
| (n=41) | (n=48) | (n=23) | (n=43) | |||
| Note: one outlier with ALT = 159 | ||||||
| Creatinine (mean (SD)) | 0.73 (0.16) | 0.83 (0.32) | .04 | 0.75 (0.13) | 0.78 (0.42) | .67 |
| (n=51) | (n=51) | (n=35) | (n=44) | |||
| Significant Proteinuria (n (%)) | 1/51† (2.0) | 14/52† (26.9) | <.0001 | 0/35 (0) | 7/44 (15.9) | .01 |
| Peripheral Nerve Involvement (n (%)) |
1/1† (100) | 50/50† (100) | 0/1† (0) | 41/41† (100) | ||
| Peripheral Nerve Severity (n (%)) | ||||||
| 1 | 1 (100) | 7 (14) | 5 (12.2) | |||
| 2 | 20 (40) | 20 (48.8) | ||||
| 3 | 10 (20) | 7 (17.1) | ||||
| 4 | 7 (14) | 3 (7.3) | ||||
| 5 | 6 (12) | 6 (14.6) | ||||
| Cardiac Involvement (n (%)) | 0/1† (0) | 28/51† (56.0) | 1/2† (50.0) | 30/41† (73.2) | ||
| Cardiac Severity (n (%)) | n=28 | n=1 | n=30 | |||
| Mild | 10 (35.7) | 13 (43.3) | ||||
| Moderate | 9 (32.1) | 1 (100) | 8 (26.7) | |||
| Severe | 9 (32.1) | 9 (30.0) | ||||
| Diabetes (n (%)) | 1/1† (100) | 3/52† (5.8) | 0/0† | 0/40† (0) | ||
†denominator is number with a yes or no answer to the question.
*t-test for continuous variables, chi-square for categorical variables.