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PET imaging groups.
| Group | N | Tumor model | PET tracer | SA (GBq/µmol) |
|---|---|---|---|---|
| Subcutaneous xenograft | ||||
| 1 | 4 | HepG2(R)/Huh7(L) | 89Zr-Df-YY146 | 44.4 |
| 2 | 3 | HepG2(R)/Huh7(L) | 89Zr-Df-YY146 + YY146 (50 mg/kg) | 44.4 |
| 3 | 5 | HepG2 | 89Zr-Df-YY146-ZW800 | 18.5 |
| 4 | 3 | HepG2 | 89Zr-Df-YY146-ZW800 | 29.6 |
| 5 | 4 | HepG2 | 89Zr-Df-YY146-ZW800 + YY146 (50 mg/kg) | 29.6 |
| 6 | 3 | Huh7 | 89Zr-Df-YY146-ZW800 | 29.6 |
| Orthotopic xenografts | ||||
| 7 | 4 | HepG2 | 89Zr-Df-YY146-ZW800 | 29.6 |
| 8 | 5 | HepG2 | 89Zr-Df-YY146-ZW800 | 18.5 |
| R: right flank; L: left flank; SA: specific activity | ||||
