Figure 4.

Real-time intravital imaging showed that over-expression of GPx3 significantly suppressed HCC invasiveness. (A) Ectopic nude mice liver cancer model with dorsal window chamber was established. (B) HCC cells gradually invaded into surrounding connective tissues at different time points in the control group. In the contrast, HCC cells with over-expression of GPx3 remained intact. Yellow arrow heads indicated invasive tumor cells. (C) Three-dimension reconstructed images showed that HCC cells invaded into surrounding connective tissues in Z-axis as early as 2 weeks after innoculation. However, the invasiveness of HCC cells with over-expression of GPx3 was significantly inhibited.