TABLE 1.

Fraction of VA in compartment J transferred to compartment I per day in neonatal rats dosed with placebo or 50,000 IU VA on postnatal day 4¹

		L(I,J),2 pools/d
Fractional transfer coefficient	Parameter description	Control group	VA group	df	P
L(18,10)	Uptake of CM REs into the brain	0.31 ± 0.12	1.17 ± 0.05	7	<0.001
L(0,18)	Loss of CM-derived retinol from the brain	0.59 ± 0.20	1.40 ± 0.28	7	<0.05
L(8,1)	Uptake of RBP retinol into the brain	0.53 ± 0.04	0.17 ± 0.01	7	<0.05
L(0,8)3	Loss of RBP-derived retinol from the brain	11.43 ± 1.05	3.42 ± 0.47	7	<0.01

¹CM, chylomicron; L(I,J), fractional transfer coefficient, representing the fraction of dose transferred from compartment (J) to compartment (I); RBP, retinol-binding protein; RE, retinyl ester; VA, vitamin A.

²Values are means ± SEMs.

³L(0,8) is the mean of L(0,8) and P(0,8) introduced by applying a time interrupt 1 day after dose administration.