TABLE 3.
Unadjusted predictors of treatment failure1
| Characteristic | Unknown | Overall (n = 182) | Cholestasis resolved (n = 156) | Treatment failure (n = 26) | P |
| Males | 0 | 104 (57) | 88 (56) | 16 (62) | 0.62 |
| Caucasians | 0 | 126 (69) | 111 (71) | 15 (58) | 0.17 |
| Hispanics | 2 | 35 (19) | 31 (20) | 4 (15) | 0.57 |
| Birth gestational age, wk | 9 | 32 (26, 36) | 32 (26, 36) | 31 (26, 34) | 0.30 |
| Birth weight, g | 17 | 1475 (800, 2305) | 1608 (815, 2438) | 1020 (737, 1776) | 0.03 |
| Extremely low birth weight (<1 kg) | 17 | 57 (35) | 47 (33) | 10 (48) | 0.18 |
| Birth length, cm | 80 | 41.7 (34.0, 46.5) | 42.0 (34.5, 47.0) | 36.2 (32.0, 41.5) | 0.05 |
| Age at PN start, d | 6 | 1.0 (0.0, 2.0) | 1.0 (0.0, 2.0) | 1.0 (0.0, 2.0) | 0.59 |
| Age at FO start, wk | 7 | 12.7 (7.7, 24.9) | 11.7 (7.3, 21.4) | 20.4 (9.9, 38.6) | 0.02 |
| ≤14 d FO therapy | 3 | 6 (3) | 4 (3) | 2 (8) | 0.18 |
| Ever exclusive enteral feeding | 2 | 33 (18) | 27 (17) | 6 (24) | 0.41 |
| Any prior operations | 1 | 173 (96) | 149 (96) | 24 (96) | 1.00 |
| Stoma2 | 3 | 88 (49) | 77 (50) | 11 (44) | 0.58 |
| Duodenostomy | 3 | 9 (5) | 9 (6) | 0 (0) | 0.36 |
| Jejunostomy | 3 | 42 (23) | 38 (25) | 4 (16) | 0.34 |
| Ileostomy | 3 | 37 (21) | 31 (20) | 6 (24) | 0.66 |
| Colostomy | 3 | 4 (2) | 3 (2) | 1 (4) | 0.46 |
1
Values are n (%) or medians (IQRs) unless otherwise noted. P values are from Pearson’s chi-square or Fisher’s exact tests if categorical and Wilcoxon’s rank-sum test otherwise. FO, fish oil; PN, parenteral nutrition.
2
Stoma location, if present, at time of FO therapy initiation (most proximal if multiple).