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. 2016 Aug 25;6:31973. doi: 10.1038/srep31973

Table 1. DNA binding properties of 1 and 2 and impact on cell proliferation.

  IC50 (μM)
Compound Log P DNA Kb (M−1) HeLa MCF7 HFF
1 0.403 2.5 × 106 38 28 >100
2 0.076 6.7 × 107 14 12 >100
Cisplatin −2.3 N/A 9 11 >100
MX 0.36 5 × 106 3.0 3.6 4.2

Log P = octanol/water partition coefficient. Kb (M−1) determined from hypochromic shifts on addition of DNA. IC50 values were derived from 24 h proliferation assays.