Table 2. Multivariate analysis of major bleeding in 4824 patients with AF.

	OR	95%CI		P
		Lower limit	Higher limit
Prior bleeds	13.82	5.52	34.61	<0.001
Vascular disease	6.24	2.24	17.39	<0.001
Anemia	6.19	2.21	17.34	0.001
Prior stroke	5.00	2.62	9.53	<0.001
Liver dysfunction	3.91	1.03	14.90	0.045
Hypertension	1.70	0.89	3.24	0.106
Heart failure	1.27	0.35	4.57	0.714
Age	1.00	0.98	1.03	0.840
Diabetes	0.87	0.43	1.77	0.699
Female	0.85	0.47	1.55	0.604
Renal dysfunction	0.84	0.30	2.34	0.734
Antiplatelet	0.72	0.37	1.42	0.344

*OR: odds ratio. Vascular disease: carotid atherosclerosis, peripheral vascular disease, vascular amyloidosis, vascular dementia.