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. 2016 Aug 25;6:32036. doi: 10.1038/srep32036

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Copyright © 2016, The Author(s)

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(A) The Lineweaver-Burk plot for inhibition of ETC by exactin. Both kcat and Km decreased with the increase in inhibitor concentration (Table S1), characteristic of mixed-type inhibition. (B,C) Corresponding secondary plots depicting Ki’ obtained towards the [ES] complex (FVIIa/TF/FX/phospholipids) and Ki obtained towards the [E] complex (FVIIa/TF/phospholipids). (D) The Lineweaver-Burk plot for the inhibition of FVIIa/phospholipids by exactin. Both kcat and Km decreased with increase in inhibitor concentration (Table S2), characteristic of mixed-type inhibition. (E,F) Corresponding secondary plots depicting Ki’ obtained towards the [ES] complex (FVIIa/FX/phospholipids) and Ki obtained towards the [E] complex (FVIIa/phospholipids). (G) The Lineweaver-Burk plot for inhibition of FVIIa/sTF by exactin. Both kcat and Km decreased with increase in inhibitor concentration (Table S3), characteristic of mixed-type inhibition. (H,I) Corresponding secondary plots depicting Ki’ obtained towards the [ES] complex (FVIIa/sTF/FX) and Ki obtained towards the [E] complex (FVIIa/sTF). Each data point represents the average ± SD of three to five independent experiments.