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. 2016 Aug 25;6:31753. doi: 10.1038/srep31753

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Venn diagram showing overlap between Arc-dVenus-enriched genes, genes regulated by activity in vitro¹², visual stimulus-regulated genes¹³, and genes enriched in Fos+ hippocampal neurons²⁹. Arc-dVenus-enriched genes are defined by FDR <0.05 and fold-enrichment of >2 in Arc-dVenus+ neurons (n = 5) compared to bulk-tissue controls (n = 3). (B) Heatmap of expression in Arc-dVenus+ neurons and bulk-tissue for genes that are both Arc-dVenus-enriched and activity- or visual stimulus-regulated. Each gene’s expression is normalized to its mean across the three bulk-tissue samples. (C,D) The expected versus actual numbers of Arc-dVenus-enriched genes that are also visual stimulus-induced (C) or activity-induced (D) (p < 10⁻²⁰, hypergeometric tests). Distributions of expected numbers from the hypergeometric distribution are in black; actual numbers are in red.