Table 3.
Systemic inflammatory and endothelial biomarkers across tertiles of vitamin D status.
| Marker | Tertile 1 (N = 25) | Tertile 2 (N = 29) | Tertile 3 (N = 29) |
|---|---|---|---|
| 25(OH)D (nmol/L) | 97.0 (83.0–202.6) | 74.5 (66.0–83.0) | 56.8 (26.3–65.4) |
| TNF–α (pg/mL) | 5.40 (3.80–9.12) | 4.40 (3.10–6.00) | 4.10 (3.10–6.46) |
| CRP (ng/L) | 2134.50 (933.00–9120.00) | 2079.00 (891.00–4467.00) | 2359.00 (1122.0–9550.0) |
| Leptin (pg/mL) | 7952 (4074–79433) | 11871.4 (3020–40738) | 8323.40 (2692–51286) |
| D–dimer (pg/mL) | 2538 (1318–3162) | 2258 (1513–3548) | 1958 (1122–3630) |
| sICAM-1 (pg/mL) | 126.00 (109.6–144.5) | 114.40 (95.5–141) | 132.77 (117.5–158.5) |
| MPO (pg/mL) | 358.00 (302.00–447.00) | 309.00 (219.00–417.00) | 399.00 (288.40–489.80) |
| P-selectin (pg/mL) | 130.00 (115.00–186.00) | 141.00 (100.00–199.50) | 159.00 (104.70–195.00) |
| sVCAM-1 (pg/mL) 1 | 877.00 * (708.0–955.00) | 705.80 (616.50–832.00) | 703.00 (602.60–891.30) |
| HGF (pg/mL) | 512.50 ** (355.00–633.50) | 351.60 (263.00–509.00) | 318.50 (219.00–426.80) |
Data are predicted median (range) from MANCOVA model that initially adjusted for age, gender, BMI, McAuley’s index, season, medications and PTH, but season, medications and PTH were excluded in the final model by a backward elimination procedure. 1 Overall MANOVA, p = 0.091 for sVCAM but p < 0.05 for HGF. Post-hoc tests * p < 0.05; ** p < 0.01 vs. Tertile 3. TNF-α, tumor necrosis factor-alpha; CRP, C reactive protein; sICAM, soluble intracellular adhesion molecule; MPO, myeloperoxidase; sVCAM, soluble vascular cell adhesion molecule; HGF, hepatocyte growth factor.