Table 3.

Concurrent effect of methyl-group donor intake on DNA (hydroxy)methylation.

Concurrent Intake	DNA Methylation	DNA Hydroxymethylation
	p (Slope)	p (Slope)
	95% CI	95% CI
Methionine	0.7 (0.007)	0.83 (−0.0002)
	−0.03–0.04	−0.0023–0.0018
Folate	0.99 (0.001)	0.28 (−0.006)
	−0.2005–0.203	−0.02–0.005
Folic acid	0.04 (0.042)	0.04 (0.002)
	0.001–0.08	0.0001–0.004
Choline	0.62 (0.056)	0.89 (−0.001)
	−0.17–0.28	−0.0135–0.0117
Betaine	0.87 (0.023)	0.79 (−0.002)
	−0.26–0.31	−0.19–0.01

Slope> (<) 0: increase of nutrient level implies an increase (decrease) of the global DNA (hydroxyl)methylation level.