Table 2.
Orthogonal projection to latent structure-discriminant analysis (OPLS-DA) coefficients derived from the NMR data of urine metabolites obtained from the (A) control, (B) glutamine, and (C) N-carbamylglutamate groups.
| Metabolite | B (vs. A) a | C (vs. A) a | B (vs. C) a |
|---|---|---|---|
| Acetamide (13) | 0.608 | −0.728 | 0.906 |
| Acetate (12) | 0.713 | −0.742 | 0.768 |
| Citrulline (11) | 0.758 | −0.962 | 0.966 |
| Creatine (26) | — | −0.790 | 0.783 |
| Creatinine (27) | 0.723 | 0.717 | — |
| Ethanol (6) | −0.630 | 0.692 | −0.631 |
| Formate (51) | −0.621 | — | — |
| Glycine (34) | — | −0.616 | — |
| Hippurate (37) | — | −0.914 | 0.906 |
| Homogentisate (43) | — | −0.810 | 0.834 |
| Indoxyl sulfate (46) | — | 0.786 | −0.786 |
| Lactate (9) | — | 0.653 | — |
| Methylmalonate (7) | 0.738 | 0.608 | −0.653 |
| N-Acetylglutamate (14) | — | −0.967 | 0.978 |
| Phenylacetyglycine (36) | — | −0.634 | — |
| α-Hydroxy-n-valerate (8) | −0.684 | — | — |
| α-Ketoglutarate (19) | — | — | −0.623 |
| Acetoacetate (16) | — | 0.786 | −0.815 |
| Acetone (15) | — | −0.912 | 0.944 |
| m-Hydroxyphenylacetate (45) | — | 0.815 | −0.883 |
| p-Hydroxyphenylacetate (44) | — | −0.813 | 0.844 |
| Sarcosine (35) | — | 0.865 | −0.853 |
| α-Hydroxy-iso-valerate (2) | — | 0.607 | — |
| Pyruvate (4) | — | — | −0.608 |
| Methylamine (21) | — | — | −0.635 |
a Correlation coefficients: positive and negative signs indicate positive and negative correlations in the concentrations, respectively. The correlation coefficient of |r|> 0.602 was used as the cutoff value. ‘‘—’’ means the correlation coefficient |r| is less than 0.602. Analysis of relative integral from metabolites was given in Table S1 (Supplementary Material).