Table 3.
Relative risks of LGA and SGA in pregnant women according to folic acid supplementation after early pregnancy * (relative risk (RR) and 95% confidence interval).
| RRe | Group 1 | Group 2 | Group 3 | Group 4 |
|---|---|---|---|---|
| n = 2181 | n = 109 | n = 223 | n = 131 | |
| Risk of LGA birth | ||||
| model 1 | 1 | 0.99 (0.58, 1.69) | 1.25 (0.87, 1.78) | 1.88 (1.25, 2.83) ** |
| model 2 | 1 | 0.99 (0.58, 1.68) | 1.24 (0.86, 1.77) | 1.85 (1.23, 2.79) ** |
| model 3 | 1 | 0.98 (0.59, 1.70) | 1.26 (0.88, 1.80) | 1.97 (1.30, 2.98) ** |
| model 4 | 1 | 1.05 (0.61, 1.80) | 1.32 (0.92, 1.90) | 2.07 (1.36, 3.15) ** |
| model 5 | 1 | 1.05 (0.61, 1.80) | 1.29 (0.89, 1.87) | 1.98 (1.29, 3.04) ** |
| Risk of SGA birth | ||||
| model 1 | 1 | 0.53 (0.23, 1.21) | 0.75 (0.45, 1.25) | 0.91 (0.50, 1.68) |
| model 2 | 1 | 0.54 (0.23, 1.24) | 0.75 (0.45, 1.26) | 0.99 (0.54, 1.85) |
| model 3 | 1 | 0.53 (0.23, 1.22) | 0.74 (0.44, 1.25) | 0.92 (0.50, 1.71) |
| model 4 | 1 | 0.51 (0.22, 1.19) | 0.74 (0.44, 1.25) | 0.80 (0.43, 1.51) |
| Model 5 | 1 | 0.55 (0.23, 1.27) | 0.77 (0.45, 1.29) | 0.90 (0.48, 1.70) |
* Model 1 is crude RR. Model 2 adjusts for maternal age in pregnancy and the newborn’s gender; model 3 includes further adjustment for maternal BMI before pregnancy; model 4 plus maternal education level, family monthly income per capita, parity, area of residence, maternal smoking status, alcohol consumption and calcium supplementation; model 5 plus gestational diabetes mellitus and gestational hypertension; ** p < 0.01 compared with Group 1 (reference).