Table 5.
Interaction of risk factors for pre-diabetes.
| Factor 1 | Factor 2 | Additive Interaction | Multiplicative Interaction | ||||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | RERI (95% CI) | AP (95% CI) | S (95% CI) | AOR * (95% CI) | p | ||
| Overweight/Obesity | Hypertension | ||||||
| + | + | 2.009 (1.655–2.439) | 0.248 (−0.203–0.700) | 0.124 (−0.096–0.343) | 1.326 (0.749–2.348) | 1.262 (0.840–1.897) | 0.262 |
| + | − | 1.360 (1.056–1.751) | |||||
| − | + | 1.403 (1.162–1.693) | |||||
| − | − | 1 | |||||
| Overweight/Obesity | TG ‡ | ||||||
| + | + | 2.005 (1.641–2.451) | 0.403 (−0.046–0.853) | 0.201 (−0.005–0.407) | 1.669 (0.875–3.183) | 1.228 (1.023–1.473) | 0.027 |
| + | − | 1.335 (1.117–1.595) | |||||
| − | + | 1.268 (1.027–1.565) | |||||
| − | − | 1 | |||||
| Hypertension | TG ‡ | ||||||
| + | + | 2.034 (1.640–2.522) | 0.602 (0.146–1.058) | 0.296 (0.091–0.501) | 2.394 (0.915–6.264) | 1.156 (1.002–1.332) | 0.047 |
| + | − | 1.331 (1.097–1.614) | |||||
| − | + | 1.101 (0.820–1.477) | |||||
| − | − | 1 | |||||
OR, odds ratio; AOR, adjusted odds ratio; CI, confidence interval; RERI, relative excess risk of interaction; AP, attributable proportion of interaction; S, synergy index; TG, triglyceride; BMI, body mass index; normal: BMI < 24 kg/m2; overweight/obesity: BMI ≥ 24 kg/m2; * Adjusted for age, sex, marital status, education level, smoking, drinking, physical activity, diet, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol; ‡ In the additive model, TG was presented as a categorical variable; in the multiplicative model, TG was presented as a continuous variable.