. 2016 Aug 4;115(5):624–631. doi: 10.1038/bjc.2016.228

Table 1. Effect estimates for plasma phospholipid levels of polyunsaturated fatty acids (PUFAs, % of total fatty acids) for genome-wide significant (P<5 × 10⁻⁸), independent (r ² <0.1) genetic variants reported from previous GWAS.

Chr	SNP	GRCh37/hg19 position	Allelea	EAF	β	s.e.	P-value	% VEb per allele	% VE per IVc	F-statistic per IVd
Linoleic acid (LA, 18:2n6)
10	rs10740118	65101207	C/G	0.56	0.248	0.043	8.08 × 10⁻⁹	0.2–0.7
11	rs174547	61570783	T/C	0.32	1.474	0.042	4.98 × 10⁻²⁷⁴	7.6–18.1
11	rs2727270	61603237	T/C	0.44	0.690	0.070	2.60 × 10⁻²¹	0.5–2.4
16	rs16966952	15135943	A/G	0.31	0.351	0.044	1.23 × 10⁻¹⁵	0.5–2.5	8.8–23.6e	1104–3533
Arachidonic acid (AA, 20:4n6)
11	rs174547	61570783	T/C	0.68	1.691	0.025	3.00 × 10⁻⁹⁷¹	32.63
16	rs16966952	15135943	A/G	0.69	0.199	0.031	2.43 × 10⁻¹⁰	0.44	33.07	11 302
α-Linolenic acid (ALA, 18:3n3)
11	rs174547	61570783	T/C	0.33	0.016	0.001	3.47 × 10⁻⁶⁴	1.03	1.03	476
Eicosapentaenoic acid (EPA, 20:5n3)
6	rs3798713	11008622	C/G	0.43	0.035	0.005	1.93 × 10⁻¹²	0.36
11	rs174538	61560081	A/G	0.72	0.083	0.005	5.37 × 10⁻⁵⁸	1.69	2.05	479
Docosapentaenoic acid (DPA, 22:5n3)
2	rs780094	27741237	T/C	0.41	0.017	0.003	9.04 × 10⁻⁰⁹	0.46
6	rs3734398	10982973	T/C	0.43	0.040	0.003	9.61 × 10⁻⁴⁴	2.74
11	rs174547	61570783	T/C	0.67	0.075	0.003	3.79 × 10⁻¹⁵⁴	8.38	11.58	1997
Docosahexaenoic acid (DHA, 22:6n3)
6	rs2236212	10995015	C/G	0.57	0.113	0.014	1.26 × 10⁻¹⁵	0.65	0.65	299

Abbreviations: EAF=effect allele frequency; IV=instrumental variable; s.e.=standard error; SNP=single-nucleotide polymorphism.

Allele associated with an increase in PUFA levels is in bold, and is considered the effect allele.

% variation explained (VE)=(2 × β² × EAF × (1−EAF)/var(PUFA)) × 100.

% VE per IV=sum of the %VE per allele for each SNP included in the IV.

F-statistic is a measure of the strength of the genetic instrument and is calculated as follows: (R² × (n-1-k))/((1-R²) × k), where R²=% variation explained, n= sample size, k=total number of instrumental variables.

Ranges for % VE per SNP and % VE IV as reported in Guan et al (2014).

Table 1. Effect estimates for plasma phospholipid levels of polyunsaturated fatty acids (PUFAs, % of total fatty acids) for genome-wide significant (P<5 × 10−8), independent (r 2 <0.1) genetic variants reported from previous GWAS.

Table 1. Effect estimates for plasma phospholipid levels of polyunsaturated fatty acids (PUFAs, % of total fatty acids) for genome-wide significant (P<5 × 10⁻⁸), independent (r ² <0.1) genetic variants reported from previous GWAS.