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. 2016 Aug 25;6:32288. doi: 10.1038/srep32288

Figure 3. Monocytes require IFNβ-mediated communication with other leukocytes to produce MCP- 1 in response to CHIKV infection.

Figure 3

(a) Treatment of PBMCs with αIFNAR1/2 antibody abolished CHIKV-mediated MCP-1 production. Bars represent mean + s.e.m., n = 3. (b) Treatment of PBMCs with JAK inhibitor Ruxolitinib (Rux) reduced IFNβ- and CHIKV-mediated MCP-1 production. Bars represent mean + s.e.m., n ≥ 2. (c) Addition of IFNβ-pretreated MoΔPBMCs to monocytes triggered MCP-1 production measured 24 h post co-culture. Bars represent mean + s.e.m., n = 2.