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. 2016 Aug 24;13:48. doi: 10.1186/s12989-016-0159-z

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Serum Cytokine Concentrations Following IT instillation of PVP Capped AgNP. Graphs presenting mean serum concentration of selected cytokines 1 day (panels a, c, e and g) and 7 days (panels b, d, f and h) after IT instillation. Cytokines IL-2 (a) IL-6 (c) IL-18 (d) and G-CSF (e) were modestly elevated compared to citrate vehicle 1 day following IT instillation. At 7 days following instillation cytokine concentration was not elevated above vehicle. (b) denotes statistical significance from vehicle, (c) denotes significance from other AgNP particle size within a capping agent. p < 0.05 by one-way ANOVA, Data are reported as mean ± SEM with n = 4–8