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. 2016 Aug 25;8(1):91. doi: 10.1186/s13073-016-0341-9

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Power comparison between fitDNM, Poisson-all, Poisson-LGD, and VARPRISM. Left: Power benchmark using de novo mutations in ASD risk genes as damaging mutations. Right: Power benchmark using Human Gene Mutation Database (HGMD) variants as damaging mutations. The sample size is 5000 genomes and the number of trials is 1000. We set the statistical significance threshold at 5 × 10^–4