Table 2. List of HLA class I restricted T-cell epitopes included in Ad-MvP.
| Virus | Sequencea | Antigen | HLA restriction |
|---|---|---|---|
| BKV | MLTERFNHIL | large T antigen | A*02 |
| LLLIWFRPV | large T antigen | A*02:01 | |
| SITEVECFL | VP1 | A*02:01 | |
| LPLMRKAYL | large T antigen | B*07:02, B*08 | |
| RLDSEISMY | large T antigen | A*01 | |
| SVKVNLEKK | large T antigen | A*03 | |
| AYLRKCKEF | large T antigen | A*24 | |
| ADV | TDLGQNLLY | hexon protein | A*01 |
| TYFSLNNKF | hexon protein | A*24:02 | |
| MPNRPNYIAF | hexon protein | B*07, B*35 | |
| GLRYRSMLL | hexon protein | A*02:02 | |
| LPGSYTYEW | hexon protein | B*53:01 | |
| IPYLDGTFY | hexon protein | B*35, B*53:01 | |
| VLAWTRAFV | DNA polymerase | A*02 | |
| FLGRQLPKL | DNA binding protein | A*02 | |
| CMV | VTEHDTLLY | pp50 | A*01 |
| YSEHPTFTSQYb | pp65 | A*01, B*44 | |
| NLVPMVATV | pp65 | A*02:01 | |
| FPTKDVAL | pp65 | B*35:02, B*35:08 | |
| QYDPVAALF | pp65 | A*24:02 | |
| AYAQKIFKIL | IE-1 | A*23:01, A*24:02 | |
| RPHERNGFTVL | pp65 | B*07:02 | |
| ELRRKMMYM | IE-1 | B*08:01 | |
| IPSINVHHY | pp65 | B*35:01 | |
| TRATKMQVI | pp65 | C*06:02 | |
| TTVYPPSSTAK | pp150 | A*03:01, A*68:01 | |
| GPISHGHVLK | pp65 | A*11 | |
| HERNGFTVL | pp65 | B*40:01 | |
| EBV | CLGGLLTMV | LMP2a | A*02:01 |
| GLCTLVAML | BMLF1 | A*02:01 | |
| SSCSSCPLSKI | LMP2a | A*11:01 | |
| TYGPVFMCL | LMP2a | A*24:02 | |
| RPPIFIRRL | EBNA3A | B*07:02 | |
| FLRGRAYGL | EBNA3A | B*08:01 | |
| RAKFKQLL | BZLF1 | B*08:01 | |
| HPVGEADYFEYb | EBNA1 | B*35:01, B*35:08, B*53:01 | |
| YPLHEQHGM | EBNA3A | B*35:01, B*35:02, B*35:03 | |
| VEITPYKPTW | EBNA3B | B*44:02 |
ADV, adenovirus; BKV, BK virus; CMV, cytomegalovirus; EBV, Epstein-Barr virus.
a
Bold epitopes are included in the polyepitope, nonbold epitopes are delivered by the adenoviral vector.
b
Underlined sequences indicate epitopes that are embedded in the larger sequence and their respective HLA restrictions.