Fig. 3.

Landscape of CNV and promoter methylation of TFs that are silenced in cancer. Heatmaps of copy number and promoter methylation changes in six different cancer types: LSCC, LUAD, KIRC, KIRP, BLCA and COAD. In each case TFs highly expressed in the corresponding normal tissue type and which are underexpressed in cancer have been arranged along rows, using the same order for DNAm and CNV. Each column in the heatmap labels a tumour sample. For all CNV heatmaps, the colours represent the segment values assigned to the corresponding genes, as indicated. In the case of DNAm, the colours indicate the difference in beta (DNAm) value at the promoter between the cancer sample and the average of all normal tissue samples