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. 2016 Aug 22;60(9):5159–5166. doi: 10.1128/AAC.02687-15

TABLE 2.

Regions of the pncA gene correlated with low- or high-level pyrazinamide resistance

Region No. of isolates with mutation No. (%) correlated with:
Pa
Low-level PZA resistance (MIC ≤ 500 mg/liter) High-level PZA resistance (MIC > 500 mg/liter)
Codons 51–76 34 5 (14.7) 29 (85.3)
Codons 130–142 28 0 (0.0) 28 (100.0)
Codons 163–180 14 0 (0.0) 14 (100.0) <0.001
Codons 94–97 16 6 (37.5) 10 (62.5)
Nucleotide −11 to codon 16 29 21 (72.4) 8 (27.6)
a

Calculated by comparing all the codon regions of the pncA gene by using the Fisher exact test.