TABLE 2.

Summary of key univariable population PK model building process^a

Model description	Population model	OFV	Change in OFV from base model
CL (base model)	CL = θCL * (WT)0.75	9,624
PNA	CL = θCL * (WT)0.75 * (PNA/25)θCL-PNA	9,492	−132
GA	CL = θCL * (WT)0.75 * (GA/25)θCL-GA	9,599	−25
PMA	CL = θCL * (WT)0.75 * (PMA/28)θCL-PMA	9,450	−174
SCR	CL = θCL * (WT)0.75 * (SCR/0.8)θCL-SCR	9,405	−219
CSCT	CL = θCL * (WT)0.75 * θCL-CSCTCSCT	9,617	−7
V (base model)	V = θV * (WT)1.0	9,624
PMA	V = θV * (WT)1.0 * (PMA/28)θV-PMA	9,620	−4
SCR	V = θV * (WT)1.0 * (SCR/0.8)θV-SCR	9,600	−24

^aOFV, objective function value; CSCT, delivery by Cesarean section.