TABLE 3.
Final PK model parametersa
| Parameter | Symbol | Point estimate | SEE | Bootstrap CI |
||
|---|---|---|---|---|---|---|
| 2.5% | Median | 97.5% | ||||
| V (liters/kg) | θV | 1.00 | 0.0378 | 0.93 | 1.00 | 1.08 |
| CL (liters/h/kg0.75) | θCL | 0.0127 | 0.00033 | 0.0120 | 0.0127 | 0.0133 |
| F1 (%) | θF1 | 1.00 | 0.065 | 0.86 | 1.00 | 1.13 |
| ka (1/h) | θKA | 0.96 | 0.25 | 0.52 | 0.96 | 1.81 |
| SCR-CL | θSCR | −0.410 | 0.0498 | −0.53 | −0.41 | −0.32 |
| PMA-CL | θPMA | 2.05 | 0.35 | 1.23 | 2.05 | 2.62 |
| Interindividual variance (CV%) | ||||||
| V | ω2V | 13 | 61 | 1 | 13 | 18 |
| CL | ω2CL | 23 | 29 | 15 | 22 | 27 |
| F1 | ω2F1 | 31 | 73 | 1 | 22 | 50 |
| Residual variance (CV%) | σ2 | 46 | 27 | 37 | 46 | 51 |
| Additive value (ng/ml) | σ2 | 505 | 329 | 5 | 495 | 858 |
a
CI, confidence interval; CV%, percent coefficient of variation; SEE, standard error of estimate.