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Representative data on the inhibitory effects of levofloxacin (LVX) (A), moxifloxacin (MXF) (B), ciprofloxacin (CIP) (C), and DC-159a (D) on DNA supercoiling activities. The supercoiling activities against DNA gyrase complexes bearing WT GyrB, GyrB-N538D, and GyrB E540D in the presence of the indicated concentration of each quinolone are shown. R and Sc, relaxed and supercoiled pBR322 DNA, respectively.
