TABLE 2.
Mutations within QRDR-A and QRDR-B in pre-XDR-TB and XDR-TB isolates
| Mutation(s)a | No. of isolatesb |
% of all isolates | |
|---|---|---|---|
| Pre-XDR-TB | XDR-TB | ||
| GyrA | |||
| G88A | 1 | 1.1 | |
| A90V | 12 | 4 | 17.4 |
| S91P | 1 | 1.1 | |
| D94A | 11 | 11.9 | |
| D94G | 22 | 17 | 42.4 |
| D94H | 2 | 2 | 4.3 |
| D94N | 5 | 3 | 8.7 |
| D94V | 1 | 1.1 | |
| D94Y | 3 | 1 | 4.3 |
| A90V + D94A | 2 | 2.2 | |
| A90V + D94N | 1 | 1.1 | |
| GyrB | |||
| N538D | 1 | 1.1 | |
| E540D | 2 | 2.2 | |
| GyrA + GyrB | |||
| D94A + D533A | 1 | 1.1 | |
a
GyrA S95T was found in all isolates.
b
Sequential isolates with an identical gyrase mutation that were taken from a single patient were counted as only one isolate.