TABLE 3.
Mutations outside QRDR-A and QRDR-B in quinolone-susceptible and quinolone-resistant M. tuberculosis isolates
| Gene and nucleotide position(s) | Allele change(s) | Amino acid substitution(s)a | No. of isolatesb |
Spoligotype(s)c | Previously reported lineage-specific mutations (reference[s]) | |
|---|---|---|---|---|---|---|
| QS | QR | |||||
| gyrA | ||||||
| 165 | G/A | V55V | 1 | EAI1_SOM | NDd | |
| 996 | C/T | Y332Y | 1 | EAI6_BGD1 | ND | |
| 1151 and 1842 | C/T and T/C | A384V and I614I | 8 | 2 | EAI1_SOM, EAI2_NTB, EAI5, EAI6_BGD1, Manu1 | Lineage 1 (31, 32) |
| 1468 | C/A | H490N | 1 | Beijing | ND | |
| 1542 | G/A | E514E | 1 | 1 | Beijing | ND |
| 1820 | G/A | R607H | 1 | Beijing | ND | |
| 1959 | G/C | L653L | 1 | EAI2_NTB | Lineage 1.2.1 (31) | |
| 2106 | C/A | G720G | 1 | EAI5 | ND | |
| 2238 | C/T | G746G | 2 | T2 | ND | |
| gyrB | ||||||
| 261 | G/A | E87E | 11 | Manu_ancestor | ND | |
| 990 | G/C | M330I | 8 | 2 | EAI1_SOM, EAI2_NTB, EAI5, EAI6_BGD1, Manu1 | Lineage 1 (31, 32) |
| 1018 | G/T | V340L | 1 | LAM9 | Lineage 4.3.4.2 (31) | |
| 1457 | C/A | S486Ye | 1 | Beijing | ND | |
| 1651 | G/A | G551Re | 1 | 2 | Beijing | ND |
| 1933 | G/C | G645S | 1 | EAI1_SOM | ND | |
| 1966 | G/T | D656Y | 1 | Beijing | ND | |
| 2082 | C/T | D694D | 1 | EAI1_SOM | ND | |