FIG 4.
Efficacy of compound 6 (azi-NMeN-Cl-QMe) in a mouse model of pneumonia induced by S. pneumoniae SP030 Erys. Compound 6 and azithromycin were administered per os. The MIC values of compound 6 and azithromycin were ≤0.015 and 0.03 μg/ml, respectively. (A) Number of CFU per gram of lung tissue. A statistically significant reduction in the number of CFU is designated by asterisks (**, P < 0.001). (B) Concentration of compound in lung tissue 14 h after the last dose, given as mean values ± SEMs.