TABLE 4.
Activity of macrolones against quinolone-resistant S. aureus isolatesa
| Phenotype | Isolate | Genotype | MIC (μg/ml) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Compound 1 | Compound 7 | Compound 13 | Compound 19 | CIP | AZM | TEL | |||
| Erys | B 0935 | 2 | 0.25 | 0.25 | 0.125 | >64 | 0.5 | 0.06 | |
| Erys | B 0936 | 2 | 0.25 | 0.125 | 0.25 | >64 | 0.5 | 0.06 | |
| iMLSb | B 0940 | erm(C) | 1 | 0.25 | 0.25 | 0.5 | >64 | >64 | ≤0.015 |
| iMLSb | B 0941 | erm(A) | 2 | 0.25 | 0.25 | 0.5 | >64 | >64 | 0.06 |
| iMLSb | B 0942 | erm(C) | 2 | 0.125 | 0.25 | 0.5 | 32 | >64 | 0.06 |
| iMLSb | B 0943 | erm(A) | 2 | 0.25 | 0.25 | 0.5 | 8 | >64 | 0.03 |
| iMLSb | B 0944 | erm(A) | 2 | 0.5 | 0.5 | 0.5 | 32 | >64 | 0.03 |
| iMLSb | B 0950 | erm(A) | 2 | 0.25 | 0.5 | 0.5 | 16 | >64 | 0.03 |
| iMLSb | B 0538 | erm(C) | 2 | 0.25 | 0.25 | 0.5 | 32 | >64 | 0.03 |
a
The majority of isolates showed inducible resistance to macrolides as well. Erys, erythromycin susceptible; iMLSb, inducible resistance to macrolide, lincosamide and streptogramin B antibiotics; CIP, ciprofloxacin; AZM, azithromycin; TEL, telithromycin.